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Case Study S011
2025 Release

SEISMIC-HF 1 (AHA 2024): Congestion Monitoring

SEISMIC-HF Investigators et al.
Access Paper

Quick Conclusion: Provides summary evidence from the large-scale SEISMIC-HF 1 trial for non-invasive filling pressure estimation.

đź“Š Key Accuracy Metrics

MetricResult
Correlation (r)0.74
R-squared0.55
Mean difference1.04 ± 5.57 mmHg
Limit of Agreement-9.9 to 11.9 mmHg

🔍 Study Analysis

Objective & Population

Mini Review of Prospective Multi-site Observational Study (AHA 2024). Cohort: 943 patients (Analysis focused on 233 HFrEF patients) (N=943).

What it Supports

Reviews trial data showing a correlation (r=0.74) between SCG-derived metrics and invasive PCWP measurements in HFrEF patients.

What it Does Not Support

The review notes that the trial did not yet provide evidence for patients with preserved ejection fraction (HFpEF).

đź›  Technical Context

Featured Illustration

Fig. 1   Physiologic signals from non-invasive sensor for pulmonary capillary wedge pressure estimation. CardioTag (Cardiosense, Inc., Chicago, IL) is a wearable sensor patch capable of capturing seis- mocardiography, photoplethysmography, and electrocardiography

Fig. 1   Physiologic signals from non-invasive sensor for pulmonary capillary wedge pressure estimation. CardioTag (Cardiosense, Inc., Chicago, IL) is a wearable sensor patch capable of capturing seis- mocardiography, photoplethysmography, and electrocardiography

Study Snapshot

Metadata Summary

Target Population

943 patients (Analysis focused on 233 HFrEF patients)

N

Sample Size

943 Subjects

Validated Metric

0.74

Critical Appraisal
cornerstone

“Mini-review confirming accurate estimation of intracardiac filling pressures (PCWP) in HFrEF patients from the SEISMIC-HF 1 trial.”